SOPHIE MORGANI, Ph.D.
DEV BIO FLASHCARDS
Gastrulation
GASTRULATION
The process whereby the pluripotent cells
of the embryo
specify &
spatially organize the embryonic
germ layers
to establish the
future body plan of
the organism
Embryonic
stem cells
Embryonic
stem cells
Embryonic
stem cells
EMBRYONIC STEM CELLS
Cell lines derived from the early embryo that are 'pluripotent' i.e. can self-renew & have the potential give rise to the embryonic germ layers & germ cells
EPITHELIAL-MESENCHYMAL
EPITHELIAL-MESENCHYMAL
EPITHELIAL-MESENCHYMAL
EPITHELIAL-MESENCHYMAL
TRANSITION (EMT)
EMT
A cellular switch from an epithelial state, where cells are arranged in a layer through strong connections with one another, to a mesenchymal state, where cells are loosely connected and more migratory
GERM LAYERS
embryonic
EMBRYONIC
GERM LAYERS
The 3 embryonic germ layers, the
ectoderm
mesoderm
endoderm
are formed during gastrulation and will make all tissues and organs of the body.
ren
tia
tio
N
DIFFe
DIFFERENTIATION
This is the process whereby multipotent progenitors become more specialized.
For example, the inner cell mass of the pre-implantation embryo differentiates into the epiblast and primitive endoderm.
primitive
streak
PRIMITIVE STREAK (PS)
The region within the gastrulating embryo where pluripotent cells undergo an EMT and exit the epiblast.
Formation of the PS marks the onset of gastrulation.
development
pre-implantation
PRE-IMPLANTATION
DEVELOPMENT
The earliest period of development, before the embryo has implanted into the uterus of the mother.
In mouse, this window spans from fertilization until
~4.5 days later.
UTERUS
UTERUS
An organ that forms part of the female reproductive system, where the fetus develops & grows.
The embryo 'implants' into the wall of the uterus during pregnancy.
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post-implantation
development
POST-IMPLANTATION DEVELOPMENT
The period of development after the embryo has implanted into the uterus of the mother.
In mouse, this last from ~4.5 days post fertilization (dpf) until birth
(19-21 dpf).